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What You Need to Know About Cannabinoid Receptors

Cannabinoid sensory organs are notably vital to our overall health. However, they stay shrouded in secrecy. Some people are aware of the medical benefits of using marijuana but are not informed on how the process takes place. All of these possibilities are practical because of these receptors. 

The Endocannabinoid System(ECS)

The ECS is responsible for numerous physiological processes including painsensation, appetite, memory, and mood. Cannabinoid receptors belong to a class of cell membrane sensory glands that feature in the G protein-coupled receptor superfamily. This network of sensory organs makes up the endocannabinoid system and are throughout the body.

Cannabinoid receptors feature seven transmembrane-spanning areas as is ordinary of G protein-coupled sense organs. These receptors are stimulated by three main ligand groups: endocannabinoids, which are formed by a mammal’s body, plant cannabinoids like CBD, which are created by the marijuana plant, and synthetic or unnatural cannabinoids, for instance HU-210, which is 100-800 times stronger in potency than natural tetrahydrocannabinol.

Currently, two subclasses of cannabinoid sensory organs are well-known, and they are known as cannabinoid receptor type1 (CB1) and cannabinoid receptor type2 (CB2) respectively. 

Cannabinoid Receptors Type 1 & 2 

Cannabinoid receptor type 1 is manifested chiefly in the brain as well as the lungs, liver, and kidneys. Cannabinoid receptor type 2, on the other hand, it is widely expressed in the body’s defense system. It is also displayed in the stem cells that facilitate other blood cells. However, mounting proof suggests that there are other CB sensory organs. These novel CB receptors include non-CB2 and non-CB1, which are exposed in the cells that line the inner surface of lymphatic vessels and blood vessels and the central nervous system (CNS). 

There is a 44% similarity in the protein sequencing between cannabinoid receptor type 1 and type 2. The amino acid connection between the two sensory organ subtypes is close to 68% when only the transmembrane regions of the receptors are considered with insignificant variations in every receptor being determined.The cannabinoid receptors bind the cannabinoid reversibly and super-selectively. Theoretically, certain diseases like obesity can be cured by subclass selective cannabinoids that have been formed. If you are considering this health benefit, check out berkshirecbd.com.

Cannabinoid sensory organs are exclusive to the phylum Chordata, which is why they have a somewhat restricted phylogenetic pattern in the animal kingdom. Nevertheless, enzymes responsible for biosynthesis and dormancy of endocannabinoids and endocannabinoid signaling transpire throughout the animal realm. Other organisms can still process endocannabinoids through other systems even though cannabinoid receptors are exclusive to Chordates.

Other Similar Receptors

Whenever a cannabinoid substance is introduced into the body, e.g. by smoking marijuana, a cannabinoid from the plant attaches to the CB1 receptor in the brain and creates a high sensation. While tetrahydrocannabinol, a plant cannabinoid, and anandamide, which is produced in the body, are similar, anandamide doesn’t get you high like THC from plants but does have a calming effect.

The endocannabinoid system or structure is linked to the homeostasis of the body. In an occurrence where an external force such as discomfort from an impairment messes up your body’s homeostasis, your endocannabinoid structure kicks in to assist your body in returning to its optimal operation. Thus, experts believe that maintaining homeostasis is the primary function of the endocannabinoid system.

It is not surprising that cannabis is helpful to our bodies in numerous ways. Nonetheless, further studies need to be conducted for ultimate conclusions on the plant’s full capabilities.